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In one other examine, male F rats were treated with three intraperitoneal injections of 3-methyl-. Based on the examine of Yeung et al.
Thyroid glands from all surviving F zero parents have been examined microscopically, and mind measurements were performed on all uncovered F 1 pups and those F 1 pups chosen for behavioural testing. There have been no significant sex variations. In females, a larger proportion was excreted as sulfate conjugate, whereas males excreted the next proportion of a diconjugate each sulfate and glucuronide groups. From these data, the authors concluded that male rats have a better capacity for glucuronidation than females.


Other pores and skin results had been hyperplasia, hyperkeratosis, inflammation, and sebaceous gland hyperplasia, whereas there were no systemic remedy-related lesions. With resorcinol, a number of initiation—promotion research with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group have been treated with two subcutaneous injections of. In a examine carried out by Hasegawa et al.
Determination of resorcinol conjugates within the h urine samples after 14 days of continuous product treatment confirmed that a maximal 23 mg 2. Assuming a body weight of sixty four kg IPCS, offers an publicity estimate of 0. In a report primarily based on consumer research data Gans, , beneath cheap most-use circumstances i.
There is no guideline examine on toxicity for aquatic crops available. As only one concentration was tested, the examine can't be used in the danger evaluation. There are several research out there on acute toxicity to different fish species.
One issue rising potential poisonous results is the appliance of resorcinol to injured pores and skin Cassano et al. Surviving F 0 parental and F 1 following choice rats underwent complete gross necropsy following the breeding period seven F 0 males per group , following completion of weaning of F 1 pups F zero females , following scheduled necropsy of F 0 females remaining seven F zero males per group , on PND 28 F 1 uncovered pups , or on PND 30 or 70 F 1 pups chosen for behavioural testing.


In in vitro human skin studies, resorcinol was evaluated from a consultant hair dye formulation that contained 0. However, it ought to be considered that acned skin could also be broken due either to scratching or to the blemishes themselves.





  • In addition, male rats have greater circulating ranges of TSH than females.




  • British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat.




  • There isn't any indication as to whether the teratogenic effects had been endocrine mediated or not EC, c.




  • Sacrificed animals confirmed brown-dyed abdomen walls and filling of abdomen and small gut with a dark-brown to orange substance.




  • In the atmosphere, resorcinol is rapidly degraded half-life about 2 h by response with photochemically produced hydroxyl radicals.




  • Flaked resorcinol triggered no perceptible to reasonable irritation intact skin or no perceptible necrosis abraded skin.







Apart from one optimistic single case-examine Vilaplana et al. In these cases, the tested concentration of resorcinol was 0. The knowledge are summarized in Table eight. Data in regards to the totally different job categories were not supplied.
In , medical examinations see above and thyroid assessments were carried out with of presumably energetic plant workers males and 33 ladies. Flaked resorcinol brought on no perceptible to reasonable irritation intact skin or no perceptible necrosis abraded pores and skin.
Hence, an improved biodegradation fee leads to lowered risks for the setting. Regarding the consequences of resorcinol on aquatic species, the toxicity knowledge set consists of a variety of species from totally different trophic levels. Results from tests with completely different aquatic species from different trophic ranges can be found for the acute toxicity of resorcinol to aquatic organisms.

A concentration of zero. These substances were discovered to be potent inhibitors of thyroid peroxidase or I organification. Resorcinol as well as 2- and 5-methylresorcinol had been reported to be At an iodide concentration of 0.

Fifty per cent of survivors had been sacrificed 1 week later, and blood and urine samples were taken. Resorcinol showed a concentration-dependent enhance in labelling index [ 3 H]thymidine , acanthosis, and papillomatosis. After application of an ointment containing To examine the goitrogenic activity of resorcinol, feminine Wistar rats have been handled twice daily for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.
For the benthic and terrestrial compartments, the out there toxicity data cannot be considered adequate for a quantitative threat characterization. However, these compartments are much less relevant for resorcinol, due to marginal releases and emissions to those compartments in addition to a very low potential for adsorption of resorcinol to organic matter.