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Complete restoration in all animals occurred within 1—1. Of the following research, the repeated-dose toxicity research that were deemed to be most related to the chance evaluation are summarized in Appendix 6. In a study performed by NTP , 5 male and female F rats have been dosed with resorcinol in deionized water by way of gavage at zero, High-dose females had considerably decreased absolute and relative thymus weights. No other biologically significant differences in organ weights were noticed. In distinction to these findings, Eastin et al.
The elimination was biphasic, with half-lives of 18—21 min and eight. The 14 C exercise was quickly distributed in major tissues such as muscular tissues, kidneys, and liver, without indication of bioaccumulation Merker et al. Any new information being provided in the course of the OECD assessment will be supplied to the IPCS so that an addendum could be prepared for consideration.

A concentration of zero. These substances have been discovered to be potent inhibitors of thyroid peroxidase or I organification. Resorcinol as well as 2- and 5-methylresorcinol were reported to be At an iodide concentration of zero.

Different studies performed with rats and mice gave no improve within the micronucleus formation in bone marrow cells. Bone marrow smears had been ready at 30 h, and polychromatic erythrocytes per animal were scored Gocke et al. An interim sacrifice at 15 months gave no distinction in haematology, scientific chemistry, or other scientific pathology parameters and no elevated incidence of neoplasms or non-neoplastic lesions. Also, at final sacrifice, there was no evidence of carcinogenic activity in males or females of each species.
These figures agree nicely with the above publicity estimate based on the Yeung et al.
From the scarce data out there, the usage of resorcinol in hair dyes zero. The use of anti-zits cream is taken as the state of affairs of most concern due to the probability of steady exposure.

In both species, there have been no adverse effects on final imply physique weights, haematology, or medical chemistry parameters, and no chemical-related gross or microscopic lesions were observed. In one other examine, rats had been uncovered to zero or 0. No thyroid hormone measurements had been performed.

No resorcinol-related macroscopic findings, organ weight, or antagonistic microscopic target organ results have been observed in the F zero and F 1 parental animals. The F 0 and F 1 females continued to receive the resorcinol all through mating, gestation, and lactation and through the day of euthanasia for examine design, see Appendix 7. There have been no F 0 and F 1 parental resorcinol-associated deaths or scientific findings in the course of the weekly detailed bodily examinations. In controls and the high-dose group, a qualitative histopathological evaluation of the mind forebrain, midbrain, and hindbrain was also performed for the aforementioned animals RTF, There have been no antagonistic results concerning reproductive efficiency, mortality, and body or organ weights.
British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are no epidemiological knowledge relevant to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is inadequate; thus, resorcinol isn't classifiable as to its carcinogenicity to humans. JECFA assessed the hazards from the use of resorcinol as a food flavouring agent and concluded that this use is of no security concern. Overall, the research are not adequate for a statistical extrapolation technique based on the EU Technical Guidance Document EC, a.
Animals had been maintained for several months with periodic sacrifices Flickinger, The animals had been then examined weekly for 10 additional weeks. Sacrificed animals confirmed brown-dyed stomach walls and filling of abdomen and small intestine with a dark-brown to orange substance. These findings were not noted in survivors.

For the benthic and terrestrial compartments, the out there toxicity information can't be thought to be adequate for a quantitative danger characterization. However, these compartments are less related for resorcinol, due to marginal releases and emissions to these compartments in addition to a really low potential for adsorption of resorcinol to organic matter.