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In rodents, the upper sensitivity can also be associated to a shorter plasma half-life of T 4 than in humans because of considerable differences between species within the transport proteins for thyroid hormones. In plasma, the T 4 half-life is about 12—24 h in rats vs 5—9 days in humans, and the serum ranges of TSH are about 25 occasions higher in rodents than in humans.
Different studies performed with rats and mice gave no increase within the micronucleus formation in bone marrow cells. Bone marrow smears have been prepared at 30 h, and polychromatic erythrocytes per animal were scored Gocke et al. An interim sacrifice at 15 months gave no distinction in haematology, clinical chemistry, or different clinical pathology parameters and no increased incidence of neoplasms or non-neoplastic lesions. Also, at ultimate sacrifice, there was no evidence of carcinogenic exercise in males or females of both species.

Animals had been maintained for several months with periodic sacrifices Flickinger, The animals have been then examined weekly for 10 additional weeks. Sacrificed animals showed brown-dyed abdomen partitions and filling of abdomen and small gut with a darkish-brown to orange substance. These findings were not famous in survivors.

Two long-term research with Swiss mice or NZW rabbits, where the animals had been treated with zero. In an in vitro. In an investigation in three human volunteers using conditions just like those utilized in hair dyeing, 14 C-ring-labelled 1. This means that only a small quantity of resorcinol penetrates the skin during the precise process of hair colouring.

• Two lengthy-time period studies with Swiss mice or NZW rabbits, where the animals have been handled with zero.





• In rodents, the upper sensitivity can also be associated to a shorter plasma half-lifetime of T 4 than in humans due to appreciable differences between species in the transport proteins for thyroid hormones.





• No thyroid hormone measurements were carried out.





• There is not any indication as as to whether the teratogenic results were endocrine mediated or not EC, c.





• As just one concentration was tested, the examine can't be used within the threat analysis.





• In addition, male rats have larger circulating ranges of TSH than females.

Koppers Company studied potential skin irritating effects of flaked or industrial resorcinol in male albino rabbits mg under occlusive circumstances over 24 h, scoring after 24 and 72 h. In one research performed with male Syrian golden hamsters, which targeted only on results on the forestomach, pyloric area, and urinary bladder, the animals have been dosed with 0 or 0.

Fifty per cent of survivors have been sacrificed 1 week later, and blood and urine samples were taken. Resorcinol showed a concentration-dependent enhance in labelling index [ 3 H]thymidine , acanthosis, and papillomatosis. After utility of an ointment containing To study the goitrogenic exercise of resorcinol, female Wistar rats were handled twice every day for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.

The bulk of the urine-recovered dye should have been taken up into the attractive layer of the pores and skin and then slowly released into the circulation. A cumulative 4-day absorption assuming cm 2 of scalp was given as zero.

The tolerable intake of 0. It is due to this fact possible that these neurological effects are due to the acute effect of the gavage administration. CNS effects in people and animals have been associated with acute exposure to resorcinol.